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Comparison of the fungal burden in brain tissues and CSF in rabbits treated with prodrug fosmanogepix or DAMB to that of untreated control rabbits (UC) (n = 6) in a rabbit model of Candida hematogenous meningoencephalitis. Values are given as means ± SEMs. *, P ≤ 0.05; †, P ≤ 0.01. FMGX-25, fosmanogepix at 25 mg/kg BID (n = 3); FMGX-50, fosmanogepix at 50 mg/kg BID (n = 6); FMGX-100, fosmanogepix at 100 mg/kg BID (n = 6); DAMB, deoxycholate amphotericin B at 1 mg/kg (n = 6).
