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. 2021 Feb 17;65(3):e01795-20. doi: 10.1128/AAC.01795-20

FIG 3.

FIG 3

Serum and CSF (1→3)-β-d-glucan levels in a nonneutropenic rabbit model of Candida endophthalmitis and hematogenous meningoencephalitis in untreated control rabbits (UC) (n = 6) and rabbits treated with treated with prodrug fosmanogepix or DAMB. The last sample of serum was collected before euthanasia, and CSF was obtained postmortem for detection of (1→3)-β-d-glucan levels. Values are presented as means ± SEMs. *, P ≤ 0.05; †, P ≤ 0.01. FMGX-25, fosmanogepix at 25 mg/kg BID (n = 3); FMGX-50, fosmanogepix at 50 mg/kg BID (n = 6); FMGX-100, fosmanogepix at 100 mg/kg BID (n = 6); DAMB, deoxycholate amphotericin B at 1 mg/kg (n = 6).