TABLE 1.

Plasma pharmacokinetics of manogepix after multiple oral dosing of prodrug fosmanogepix and DAMB after multiple intravenous dosing^a

Drug and dose (mg/kg)	Cmax (μg/ml)	AUC0–12 (μg·h/ml)	AUC(0–24) (μg·h/ml)	CL (ml/h/kg)
Fosmanogepix
25	3.96 ± 0.41	15.78 ± 3.12		1.54 ± 0.34
50	4.14 ± 1.11	30.79 ± 5.01		1.48 ± 0.28
100	11.46 ± 1.12	95.91 ± 14.56		0.79 ± 0.18
DAMB
1	1.79 ± 0.13		15.58 ± 1.64	42.9 ± 7.04

^aAll values are expressed as the mean ± SEM. C_max, maximum concentration of drug in plasma; AUC_0–12, AUC from 0 to 12 h; AUC_0–24, AUC from 0 to 24 h; CL, clearance.