TABLE 2.
Tissue/plasma or liquid/plasma concentration ratios of manogepix administered orally as prodrug fosmanogepixa
| Tissue or liquid | Liquid/plasma concentration ration at dose of: |
||
|---|---|---|---|
| 25 mg/kg | 50 mg/kg | 100 mg/kg | |
| Aqueous humor | 0.52 ± 0.12 | 0.25 ± 0.07 | 0.19 ± 0.05 |
| Vitreous humor | 0.12 ± 0.03 | 0.12 ± 0.03 | 0.09 ± 0.02 |
| Choroid | 0.02 ± 0.00 | 0.03 ± 0.01 | 0.04 ± 0.00 |
| Cerebrum | 0.99 ± 0.02 | 0.80 ± 0.06 | 0.98 ± 0.03 |
| Cerebellum | 1.03 ± 0.05 | 1.13 ± 0.13 | 1.02 ± 0.08 |
| Spinal cord | 1.35 ± 0.13 | 1.13 ± 0.08 | 1.20 ± 0.15 |
| Meninges | 0.02 ± 0.01 | 0.02 ± 0.00 | 0.02 ± 0.00 |
| CSF | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
a
Tissue or liquid/plasma ratio calculations performed from samples obtained 1 h after the last dose of fosmanogepix on day 7 of antifungal therapy at the end of the study. All values are expressed as the ratio means.