TABLE 3.

Effects of oral prodrug fosmanogepix and DAMB on serum creatinine, urea nitrogen, ALT, and AST in a rabbit model of Candida endophthalmitis and hematogenous meningoencephalitis^a

Exptl group (no.)	Serum creatinine (mg/dl)	Serum urea nitrogen (mg/dl)	Serum ALT (U/liter)	Serum AST (U/liter)	Serum potassium (mEq/liter)
Healthy rabbits (baseline) (26)	0.93 ± 0.04	21.81 ± 0.82	28.38 ± 2.26	12.31 ± 0.72	4.07 ± 0.12
Untreated controls (6)	3.58 ± 0.99	68.50 ± 13.73	78.60 ± 16.86	91.60 ± 27.61	3.63 ± 0.48
Treatment group
FMGX-25 (3)	0.92 ± 0.10*	16.00 ± 0.58b	31.00 ± 3.22	11.33 ± 0.67b	4.00 ± 0.21
FMGX-50 (6)	1.02 ± 0.08*	15.33 ± 1.17b	24.67 ± 6.19c	14.33 ± 4.41c	3.98 ± 0.10
FMGX-100 (6)	1.65 ± 0.29	28.00 ± 7.30b	19.67 ± 1.78c	9.17 ± 0.17c	3.58 ± 0.24
DAMB (6)	2.53 ± 1.16	49.13 ± 21.44	25.30 ± 2.00c	11.83 ± 1.33c	4.26 ± 0.17

^aAll values are expressed as the mean ± SEM. Comparisons to untreated control rabbit group were performed using Mann-Whitney U test.

^bP ≤ 0.05.

^cP ≤ 0.01.