TABLE 1.

Characteristics of the population

Characteristic, median (range)	Value by dataset
	Building	Validation	Overall
No. of patients (sampling)	70 (275)	35 (99)	105 (374)
Administration route (p.o./i.v./i.v. + p.o.)	13/51/6	6/27/0	19/78/6
Oral dose (mg/kg/day)	41 (14.6–83.8)	32.4 (18.1–66.7)	36 (14.6–83.8)
i.v. dose (mg/kg/day)	10 (2.4–14.8)	10 (1.2–15.4)	10 (1.2–15.4)
No. of administrations/day (1/2/3/4)	8/56/3/3	4/30/0/1	12/86/3/4
Sex (no. male/female)	40/30	19/16	59/46
Age at inclusion (yr)	2.3 (0.2–17.3)	3.0 (0.01–16.0)	2.5 (0.01–17.3)
No. aged 0–1 yr/1–12 yr/12–18 yr	18/45/7	13/18/4	31/63/11
Body weight (kg)	11.3 (3.8–80)	14.8 (2.6–49)	11.7 (2.6–80)
Height (cm)	85 (50–178)	92 (47–165)	85 (47–178)
Serum creatinine (µmol·liter-1)	22 (10–159)	26 (5–83)	22 (5–159)
eGFR (ml/min/1.73m²)	166 (43–392)	172 (61–425)	167 (43–425)