TABLE 2.

Pharmacokinetic parameters for a BW of 11.7 kg in all children, with an eGFR of 167 ml/min/1.73 m²

Fixed population effect	Estimate (% RSE) by dataset
	Building	Building and validation
Ka (h−1)	0.55 (15)	0.506 (12)
CL (liters· h−1)	2.92 (6)	2.55 (6)
V2 (liters)	6.11 (11)	5.96 (8)
Q (liters·h−1)	0.484 (44)	0.222 (38)
V3 (liters)	1.75 (20)	1.29 (19)
F	0.444 (11)	0.438 (11)
Effect of eGFR on CLa	0.839 (8)	0.763 (7)
Effect of critically ill on CLa	0.763 (6)	0.806 (6)
IIV
ωCL	0.23 (13)	0.236 (11)
ωV	0.236 (46)	0.22 (40)
Residual variability
Residual proportional error	0.457 (5)	0.477 (4)

^aThe equations for the final model were ${\text{CL}}_i\text{\hspace{0.17em}=CL\hspace{0.17em}×}{(\frac{\text{BW}i}{11.7})}^{0.75}\text{×\hspace{0.17em}}{(\frac{\text{eGFR}i}{167})}^{0.763}\text{×0}{\text{.806}}^{\text{\hspace{0.17em}critically\hspace{0.17em}ill}}$, with critically ill equal to 0 or 1, $V_{2i}=V_2\times {(\frac{{\text{BW}}_i}{11.7})}^1$, $Q_i\text{\hspace{0.17em}=\hspace{0.17em}}Q\times {(\frac{{\text{BW}}_i}{11.7})}^{0.75}$, and $V_{3i}=V_3\times {(\frac{{\text{BW}}_i}{11.7})}^1$.