TABLE 3.

Percentage of patients with an AUC_0–24 of <40, from 40 to 80, from 80 to 120, and >120 mg/liter·h following oral administrations of doses calculated with published algorithms

Dose according to algorithm	% of patients with an AUC0–24 (mg/liter·h) of:
	<40	40–80	80–120	≥120
Pescovitz et al. dose algorithm (3)	0	12	55	33
Åsberg et al. dose algorithm (8) (applying the proposed 20% increase)	13	60	13	14
Villeneuve et al. dose algorithm (9) (interval for 28–32 mg/kg/day)	<1	53–61	20–30	11–14
Our oral proposed doses: 16, 40, and 56 mg/kg/day for low, medium, and high eGFR (maximum, 1,800 mg daily)	0	23–32	50–60	13–18