TABLE 1.
Summary statistics of baseline patient demographic, clinical laboratory, and disease-related characteristics for patients used to develop the population PK model
| Variable | n (%) | Mean | SD | Median | Min | Max |
|---|---|---|---|---|---|---|
| Age (yr) | 55 | 61.7 | 15.1 | 63.0 | 23 | 89 |
| Wt (kg) | 55 | 93.3 | 33.3 | 87.4 | 44.1 | 246 |
| Ht (cm) | 55 | 173 | 9.13 | 173 | 155 | 188 |
| Body mass index (kg/m2) | 55 | 31.2 | 10.6 | 30.4 | 16.5 | 77.9 |
| Body surface area (m2) | 55 | 2.11 | 0.38 | 2.08 | 1.42 | 3.57 |
| Serum creatinine (SCR) (mg/dl)—all patients | 55 | 2.20 | 2.42 | 1.19 | 0.3 | 13.1 |
| SCR (mg/dl)—non-RRT patients | 45 | 1.47 | 1.34 | 0.93 | 0.3 | 6.5 |
| Albumin (g/liter) | 55 | 2.29 | 0.62 | 2.40 | 1.0 | 3.6 |
| Creatinine clearance (CLCR) (ml/min/1.73 m2)—all patients | 55 | 104 | 61.4 | 97.8 | 12.5 | 380 |
| CLCR (ml/min/1.73 m2)—non-RRT patients | 45 | 102 | 63.2 | 86.5 | 21.2 | 380 |
| Sex, male | 30 (54.5) | |||||
| Race | ||||||
| Caucasian | 33 (60.0) | |||||
| Black or African American | 21 (38.2) | |||||
| Other | 1 (1.82) | |||||
| Ethnicity, non-Hispanic | 54 (98.2) | |||||
| Diabetes | 23 (41.8) | |||||
| Pulmonary hypertension | 5 (9.09) | |||||
| Renal failure | 18 (32.7) | |||||
| Heart failure | 9 (16.4) | |||||
| Hepatic failure | 6 (10.9) | |||||
| Receipt of vasopressorsa | 19 (34.5) |
a
Received any one of the following within 24 h of start of infusion until 26 h after the start of infusion: norepinephrine, epinephrine, vasopressin, dopamine, phenylephrine, and dobutamine.