TABLE 1.
MIC distribution for M. mycetomatis isolates and reproducibility and accuracy of the resazurin assay versus the XTT assay
| Antifungal agent |
M. mycetomatis isolate MIC50 (µg/ml [range]) with: |
Reproducibility of resazurin system (%) | Agreement (%) for: |
|||
|---|---|---|---|---|---|---|
| Resazurin | XTT | Resazurin vs XTT spectrometric | Resazurin visual vs spectrometric | Resazurin visual vs XTT spectrometric | ||
| Amphotericin B | 4 (1 to >8) | 4 (0.5 to >8) | 85.2 | 77.9 | 88.9 | 67.7 |
| Itraconazole | 0.016 (<0.016 to 0.5) | 0.016 (<0.016 to 0.5) | 100 | 88.9 | 100 | 77.9 |
| Micafungin | >128 (>128) | >128 (>128) | 100 | 100 | 100 | 100 |
| Posaconazole | 0.016 (<0.016 to 0.5) | 0.016 (<0.016 to 0.5) | 96.3 | 67.7 | 100 | 77.9 |
| Terbinafine | >32 (8 to >32) | >32 (8 to >32) | 92.3 | 67.7 | 77.9 | 88.9 |
| Voriconazole | 0.063 (<0.016 to 0.25) | 0.031 (<0.016 to 0.25) | 96.3 | 100 | 100 | 100 |