Comparison 4. Mechanical insufflation‐exsufflation (MI‐E) versus mechanical insufflation‐exsufflation (MI‐E) plus manually assisted cough (MAC).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Peak cough flow	1	14	Mean Difference (IV, Fixed, 95% CI)	52.80 [‐0.32, 105.92]
4.2 Inspiratory capacity	1	14	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐0.57, 0.25]