NCT01518439.

Study name	Instrumental and manual Increase of couch[sic] in neuromuscular patients (OPTICOUGH)
Methods	Open monocentric randomised cross‐over study
Participants	People with NMD with cough inefficiency in a stable respiratory state on recruitment
Interventions	Mechanical insufflation: Alpha 200 inspiratory capacity increased with a constant pressure device: Alpha 200 (presume mechanical insufflation) Mechanical insufflation + physiotherapy: Alpha 200 combined with physiotherapy – inspiratory capacity is increased with the use of constant pressure device (Alpha 200) combined with the manual pressures techniques to increase cough by the physiotherapist (presume mechanical insufflation + MAC) MI‐E: CoughAssist – increased inspiratory capacity and mechanical exsufflation with the use of insufflation‐exsufflation device (Cough Assist) MI‐E + MAC: CoughAssist + physiotherapy – increased inspiratory capacity and mechanical exsufflation with the use of insufflation‐exsufflation device (Cough Assist) + the "manual pressures techniques" (presume MAC) to increase cough by the physiotherapist (MI‐E + MAC) MAC: physiotherapist manual pressures techniques to increase cough applied by the physiotherapist (presumed MAC alone)
Outcomes	Primary outcome measures Cough flow obtained from the combination of mechanical and manual cough assistance techniques (presume PCF) Secondary outcome measures Duration of efficient PCF (> 180 L/min) for each cough assistance technique Respiratory comfort (VAS) Subjective evaluation of cough efficiency (VAS) Respiratory comfort (Borg dyspnoea scale)
Starting date	January 2012
Contact information	Contact: Helene Prigent, helene.prigent@rpc.aphp.fr Contact: Sandra Pottier, sandra.pottier@rpc.aphp.fr Principal investigator: Helene Prigent, MD, PhD Subinvestigator: Frederic Lofaso, MD, PhD Subinvestigator: David Orlikowski, MD, PhD
Notes	Attempts to contact the corresponding investigators were unsuccessful.