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. 2021 Jan 11;2021(1):CD011352. doi: 10.1002/14651858.CD011352.pub3

Comparison 3. NSAID versus a different NSAID.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 Adequate pain relief (4 hours after administration) 4   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.1 Aspirin 500 mg to 650 mg (A) versus Diflunisal 125 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.2 Aspirin 500 mg to 650 mg (A) versus Diflunisal 250 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.3 Aspirin 500 mg to 650 mg (A) versus Diflunisal 500 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.4 Aspirin 500 mg to 650 mg (A) versus Ibuprofen 300 mg to 400 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.5 Aspirin 500 mg to 650 mg (A) versus Diclofenac 25 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.6 Aspirin 500 mg to 650 mg (A) versus Diclofenac 50 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.7 Aspirin 500 mg to 650 mg (A) versus Diclofenac 100 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.8 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 25 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.9 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 50 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1.10 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 100 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2 Adequate pain relief (6 hours after administration) 5   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.1 Aspirin 900 mg (A) versus Ibuprofen 300 mg to 400 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.2 Aspirin 900 mg (A) versus Ibuprofen 900 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.3 Aspirin 500 mg to 650 mg (A) versus Diflunisal 125 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.4 Aspirin 500 mg to 650 mg (A) versus Diflunisal 250 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.5 Aspirin 500 mg to 650 mg (A) versus Diflunisal 500 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.6 Aspirin 500 mg to 650 mg (A) versus Etodolac 25 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.7 Aspirin 500 mg to 650 mg (A) versus Etodolac 100 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.8 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 25 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.9 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 50 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.10 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 100 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.2.11 Aspirin 500 mg to 650 mg (A) versus Dipyrone 500 mg (B) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.3 Need for additional analgesia (4 hours after administration) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.3.1 Aspirin 500 mg to 650 mg (A) versus Ibuprofen 300 mg to 400 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 11.00 [0.64, 190.53]
3.4 Need for additional analgesia (6 hours after administration) 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.4.1 Aspirin 900 mg (A) versus Ibuprofen 300 mg to 400 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 3.00 [0.13, 69.52]
3.4.2 Aspirin 900 mg (A) versus Ibuprofen 900 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.4.3 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 25 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.07, 16.85]
3.4.4 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 50 mg (B) 1 58 Risk Ratio (M‐H, Fixed, 95% CI) 3.00 [0.13, 70.74]
3.4.5 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) 3.20 [0.14, 75.55]
3.5 Maternal drug adverse effects (6 hours after administration) 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.5.1 Aspirin 900 mg (A) versus Ibuprofen 300 mg to 400 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 1.67 [0.46, 6.06]
3.5.2 Aspirin 900 mg (A) versus Ibuprofen 900 mg (B) 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 1.67 [0.46, 6.06]
3.5.3 Aspirin 500 mg to 650 mg (A) versus Dipyrone 500 mg (B) 1 178 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.4 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 25 mg (B) 1 61 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.5 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 50 mg (B) 1 58 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.6 Aspirin 500 mg to 650 mg (A) versus Flurbiprofen 100 mg (B) 1 60 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.7 Aspirin 500 mg to 650 mg (A) versus Diflunisal 125 mg (B) 1 65 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.8 Aspirin 500 mg to 650 mg (A) versus Diflunisal 250 mg (B) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
3.5.9 Aspirin 500 mg to 650 mg (A) versus Diflunisal 500 mg (B) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable