Suhrabi 2013.
Study characteristics | ||
Methods | Parallel RCT – 2 groups | |
Participants | Women 18 ‐ 35 years of age, vaginal birth with mediolateral episiotomy, absorbable and continuous sutures and singleton, live baby. Iran. Women were excluded if they had known allergy to NSAIDs or a history of alimentary canal disorders, underlying illness, instrumental delivery, perineal rupture (3rd or 4th degree), postpartum haemorrhage, pre‐eclampsia and eclampsia |
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Interventions | Intervention: celecoxib 100 mg every 12 hours (N = 85) Comparison: ibuprofen 400 mg every 6 hours (N = 85) |
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Outcomes |
Pain levels were measured before the intervention and at 1, 2, 4, 8 and 12 hours after suturing using a VAS; but no information provided on scale intervals 4‐hour continuous data only included in the review |
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Notes | Dates of study: March 2009 to November 2010 Funding sources: there was no funding or support Declarations of interest: none declared. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | No clear statement on method used |
Allocation concealment (selection bias) | Low risk | Sealed opaque envelopes |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Single‐blind only (the person assessing pain was blinded, but no report of blinding of the participants) |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No clear statement |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Data provided for all 170 participants (0% attrition rate in all groups) |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes were reported. |
Other bias | Low risk | No significant differences between the groups in terms of demographics or clinical characteristics |