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. 2021 Jan 11;2021(1):CD011352. doi: 10.1002/14651858.CD011352.pub3

Suhrabi 2013.

Study characteristics
Methods Parallel RCT – 2 groups
Participants Women 18 ‐ 35 years of age, vaginal birth with mediolateral episiotomy, absorbable and continuous sutures and singleton, live baby.
Iran.
Women were excluded if they had known allergy to NSAIDs or a history of alimentary canal disorders, underlying illness, instrumental delivery, perineal rupture (3rd or 4th degree), postpartum haemorrhage, pre‐eclampsia and eclampsia
Interventions Intervention: celecoxib 100 mg every 12 hours (N = 85)
Comparison: ibuprofen 400 mg every 6 hours (N = 85)
Outcomes
  • Pain levels using VAS

  • Additional analgesia (N/A for review as assume measurement at end of study period = 12 hours).

  • Adverse effects (N/A for review as assume measurement at end of study period = 12 hours).


Pain levels were measured before the intervention and at 1, 2, 4, 8 and 12 hours after suturing using a VAS; but no information provided on scale intervals 4‐hour continuous data only included in the review
Notes Dates of study: March 2009 to November 2010
Funding sources: there was no funding or support
Declarations of interest: none declared.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No clear statement on method used
Allocation concealment (selection bias) Low risk Sealed opaque envelopes
Blinding of participants and personnel (performance bias)
All outcomes High risk Single‐blind only (the person assessing pain was blinded, but no report of blinding of the participants)
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk No clear statement
Incomplete outcome data (attrition bias)
All outcomes Low risk Data provided for all 170 participants (0% attrition rate in all groups)
Selective reporting (reporting bias) Low risk All prespecified outcomes were reported.
Other bias Low risk No significant differences between the groups in terms of demographics or clinical characteristics