Comparison 3. Subgroup analyses for clinical guidelines.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Different types of financial conflicts of interest	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
3.1.1 Advisory board membership	1	5	Risk Ratio (IV, Random, 95% CI)	2.80 [0.24, 33.04]
3.1.2 Consultancy	1	5	Risk Ratio (IV, Random, 95% CI)	2.80 [0.24, 33.04]
3.1.3 Grants	1	4	Risk Ratio (IV, Random, 95% CI)	2.50 [0.20, 31.00]
3.1.4 Honoraria	1	5	Risk Ratio (IV, Random, 95% CI)	2.80 [0.24, 33.04]
3.1.5 Industry funding of the clinical guideline	1	18	Risk Ratio (IV, Random, 95% CI)	1.42 [0.88, 2.30]
3.1.6 Speaker fees	1	5	Risk Ratio (IV, Random, 95% CI)	2.80 [0.24, 33.04]
3.2 Clinical guidelines with major financial conflicts of interest versus clinical guidelines with minor financial conflicts of interest	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
3.2.1 Major financial conflicts of interest	2		Risk Ratio (IV, Random, 95% CI)	1.56 [1.05, 2.33]
3.2.2 Minor financial conflicts of interest	1		Risk Ratio (IV, Random, 95% CI)	1.06 [0.68, 1.65]