Skip to main content
. 2020 Dec 8;2020(12):MR000040. doi: 10.1002/14651858.MR000040.pub3

Ackerley 2009.

Study characteristics
Methods To analyse whether advisory committee members tend to vote in a manner that is relevant to their financial conflicts‐of‐interest. FDA drug, radiology, device, and biologic advisory committee meetings held between January 2001 and first quarter of 2008.
Data 98 advisory committee reports and 1191 committee members (611 advisory committee reports included in study (not all had data available in a format for inclusion in analysis) and 221 duplicates also included in Lurie 2006 removed).
Comparisons Advisory committee reports with financial conflicts of interest (defined as at least one committee member with financial ties to the product manufacturer or competitor) and advisory committee meetings without financial conflicts of interest
Advisory committee members with financial conflicts of interest (defined as financial ties to the product manufacturer or competitor) and advisory committee members without financial conflicts of interest
Outcomes Recommendations (favourable recommendations defined as votes in favour of the drug)
Funding source The study was commissioned by Eastern Research Group (ERG) and no additional funding related to any for‐profit organisation was disclosed
Declaration of conflicts of interest Conflicts of interest not described
Notes  
Risk of bias
Item Authors' judgement Support for judgement
Adequate document inclusion process No Only one author assessed committee meetings for inclusion (according to personal correspondence with lead author)
Adequate coding of conflicts of interest Yes The dataset was reviewed by multiple team members (according to personal correspondence with lead author)
Adequate coding of recommendations Yes The dataset was reviewed by multiple team members (according to personal correspondence with lead author)
Adequate dealing with confounding No Compared committee meetings of different drugs used for different diseases