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. 2021 Apr 23;118(17):e2015331118. doi: 10.1073/pnas.2015331118

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Fig. 4. — Correlation between monomer CIU50 stability values and PMP22 trafficking efficiencies, n = 3 (6). CIU50 values are from the 9+ monomeric charge state of PMP22 and describe the relative gas-phase stability of the protein forms. “Trafficking efficiency” is defined and the measured levels of PMP22 as the plasma membrane of model mammalian cell lines relative to the total cellular population, which include cell-internal PMP22 that is thought to be misfolded. Mutations associated with different disease severities are color coded. A quadratic regression (y = 0.3538x² − 8.4629x + 47.218) fit is shown for the data, along with errors for each dataset calculated by SD, producing a correlation coefficient of 0.80, which shows a positive correlation between monomeric protein gas-phase stability and trafficking efficiency.