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The IC50s of the FDA-approved drugs and TMZ on GSC viabilities.
| Drugs | 0827 GSC IC50 (μM, 95% CI) | 0827 d-GC IC50 (μM, 95% CI) | 0923 GSC IC50 μM (95% CI) | 0923 d-GC IC50 μM (95% CI) |
|---|---|---|---|---|
| Pyrvinium pamoate | 0.1 (0.1 – 0.2) | 0.5 (0.3 – 0.9) | 0.9 (0.7 – 1.2) | 5.3 (3.5 – 7.9) |
| Trifluoperazine | 4.7 (3.4 – 6.5) | >100 | 9.1 (6.8 – 12.5) | 35.7 (22.8 – 66.5) |
| Mitoxantrone | 1.8 (1.4 – 2.4) | 10.2 (8.5–12.2) | 2.6 (2.1 – 3.2) | 3.0 (1.9 – 4.8) |
| Temozolomide | >100 | >100 | >100 | >100 |
