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. 2021 Apr 20;118(17):e2023130118. doi: 10.1073/pnas.2023130118

Fig. 6.

Fig. 6.

PN inhibition rescues TRPV4EC channel activity in PH. (A) Effects of the UA (PN scavenger; 200 μmol/L) on TRPV4EC sparklet activity in PAs from mice treated with CH (3 wk; 10% O2) or Su+CH, expressed as NPO per site (n = 5; **P < 0.01 versus [−UA]; one-way ANOVA). (B) Scatter plot showing the FeTPPS (PN decomposer; 30 mg/kg i.p.)-induced decrease in RVSP (millimeters of mercury) in mice exposed to N or CH (n = 5 to 6; *P < 0.05; t test). (C) Effect of UA (200 μmol/L) on GSK101 (10 nmol/L)-induced vasodilation of PAs from PAH patients (n = 3; **P < 0.01; t test). (D) Effect of UA (200 μmol/L) on GSK101 (10 nmol/L)-induced TRPV4EC sparklet activity of PAs from PAH patients (n = 3; *P < 0.05; t test). (E) Effect of the UA (200 μmol/L) on TRPV4EC sparklet activity in PAs from Cav-1EC−/− mice exposed to Su+CH (n = 5). (F) Effect of UA (200 μmol/L) on GSK101 (3 to 30 nmol/L)-induced vasodilation of PAs from Cav-1EC−/− mice exposed to Su+CH (n = 5).