Table 1.

Recurrent Translocations Observed in Multiple Myeloma

Translocation	Frequency %	Partner
Immunoglobulin heavy chain (IgH) translocations
t(11;14)(q13:q32)	~15–20%	CCND1
t(4;14)(p16.2:q32)	~11–15%	FGFR3/MMSET
t(14;16)(q32:q23)	5%	c-MAF
t(6;14)(p21:q32)	<2%	CCND3
t(14;20)(q32:q11)	<1%	MAF-B
t(14; undefined)	~15%	MYC WWOX, B2M, ERF, RND3, JUN PAX5, DPF3
Immunoglobulin light chain translocations
Light chain Kappa Translocations (IgK)	4.5%	MYC
Light chain Lambda Translocations (IgL)	10%	MYC MAP3K14, CD40, MAFB, TXNDC5, CCND1, CCND2, CCND3
MYC translocations
MYC	~15–23%	IgL IgH IgK FAM46C, TXNDC5, FOXO3, BMP6, XBP1, CCND1, CCND3