5. Studies with high‐intensity psychological interventions, included in comparison 3.

Study ID	Study design	Duration of antidepressant treatment	Main disorder	Study duration	Total number randomised participants	Intervention 1	Intervention 2	Tapering scheme
Bockting 2018	RCT	≥ 24 weeks	Recurrent MDD (≥ 2 previous episodes in the last 5 years) in remission	104 weeks	143 (control group split to allow multiple‐arm comparisons)	8‐weekly PCT sessions and tapering (no placebo)	Continuation	4 weeks or longer and before 6 months (left to clinicians’ discretion)
Kuyken 2008	RCT	≥ 6 months	Recurrent MDD (≥ 3 previous episodes of depression) in full or partial remission	64 weeks	123	8‐weekly MBCT sessions and tapering (no placebo), with follow‐up sessions	Continuation	regimen determined by participants and GP
Kuyken 2015	RCT	in "maintenance" treatment	Recurrent MDD (≥ 3 previous episodes) in full or partial remission	104 weeks	424	8‐weekly MBCT sessions and tapering (no placebo), with follow‐up sessions	Continuation	regimen determined by participants and GP
Segal 2010	RCT	28 weeks	Recurrent MDD (≥ 3 previous episodes) in remission	76 weeks	40 (control group split to allow multiple‐arm comparisons)	8‐weekly MBCT sessions and tapering (no placebo), with follow‐up sessions	Continuation	4 weeks

GP: general practitioner.

MBCT: mindfulness‐based cognitive therapy.

MDD: major depressive disorder.

PCT: preventive cognitive therapy.

RCT: randomised controlled trial.