Comparison 1. Abrupt discontinuation versus continuation of antidepressants.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Relapse (as defined by study authors)	11		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
1.1.1 All studies	11	1555	Hazard Ratio (IV, Random, 95% CI)	1.97 [1.56, 2.50]
1.1.2 No co‐intervention follow‐up > 24 weeks	10	1373	Hazard Ratio (IV, Random, 95% CI)	2.09 [1.59, 2.74]
1.1.3 With co‐intervention follow‐up > 24 weeks	2	182	Hazard Ratio (IV, Random, 95% CI)	1.48 [0.93, 2.34]
1.2 Adverse events	7	1012	Odds Ratio (M‐H, Random, 95% CI)	1.11 [0.62, 1.99]
1.3 Depressive symptoms	3	330	Mean Difference (IV, Random, 95% CI)	0.44 [‐1.12, 2.00]
1.3.1 HAM‐D total score endpoint	1	140	Mean Difference (IV, Random, 95% CI)	3.40 [0.42, 6.38]
1.3.2 HAM‐D mean change	2	190	Mean Difference (IV, Random, 95% CI)	‐0.11 [‐1.54, 1.32]
1.4 Severity of illness	5	714	Mean Difference (IV, Random, 95% CI)	0.31 [0.13, 0.49]
1.4.1 CGI‐S total score	2	343	Mean Difference (IV, Random, 95% CI)	0.60 [0.27, 0.93]
1.4.2 CGI‐S mean change	3	371	Mean Difference (IV, Random, 95% CI)	0.24 [0.05, 0.43]