Comparison 3. Discontinuation with high‐intensity psychological interventions versus continuation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Relapse (as defined by study authors)	3	690	Hazard Ratio (IV, Random, 95% CI)	0.89 [0.66, 1.19]
3.2 Depressive symptoms	2	484	Mean Difference (IV, Random, 95% CI)	‐0.42 [‐1.82, 0.98]
3.2.1 HAM‐D endpoint	2	484	Mean Difference (IV, Random, 95% CI)	‐0.42 [‐1.82, 0.98]
3.3 Quality of life	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.3.1 Quality of life, physical health domain, long‐term follow‐up	2	455	Mean Difference (IV, Random, 95% CI)	‐0.22 [‐2.16, 1.73]
3.3.2 Quality of life, psychological health domain, long‐term follow‐up	2	455	Mean Difference (IV, Random, 95% CI)	0.37 [‐0.75, 1.49]
3.3.3 Quality of life, social relationships domain, long‐term follow‐up	2	455	Mean Difference (IV, Random, 95% CI)	0.05 [‐0.56, 0.66]