Comparison 4. Subgroup age, abrupt discontinuation versus continuation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Relapse (HR)	10		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
4.1.1 No co‐intervention follow‐up > 24 weeks	10		Hazard Ratio (IV, Random, 95% CI)	2.09 [1.59, 2.74]
4.1.2 Subgroup age < 65 years	3		Hazard Ratio (IV, Random, 95% CI)	1.72 [0.97, 3.05]
4.1.3 Subgroup age ≥ 65 years	2		Hazard Ratio (IV, Random, 95% CI)	2.09 [0.95, 4.60]