Molenaar 2016.

Methods	Randomised controlled trial
Participants	Pregnant women with gestational age less than 16 weeks who use SSRIs without clinically relevant depressive symptoms
Interventions	Intervention 1: preventive cognitive therapy with gradual, guided discontinuation of SSRIs under medical management Intervention 2: continuation of SSRI
Outcomes	‐ cumulative incidence of relapse or recurrence of maternal depressive disorder during pregnancy and up to 3 months postpartum ‐ child outcome (neonatal outcomes and psychomotor and behavioural outcomes up to 24 months' postpartum) ‐ healthcare costs
Notes	Unclear if participants meet the criteria for long‐term antidepressants (duration < 6 months) Miminum duration of antidepressant treatment not reported in the protocol Paper is accepted

AD: antidepressant.

GP: general practitioner.

MDD: major depressive disorder.

PHQ9: Patient Health Questionnaire‐9.

SSRI: selective serotonin reuptake inhibitor.