Duffy 2019.

Study name	A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine, and mirtazapine in preventing relapse in primary care patients who are taking long‐term maintenance antidepressants (ANTLER: aNTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial
Methods	Randomised placebo‐controlled trial
Participants	Participants between 18 and 74 years; have had at least 2 episodes of depression; and have been taking antidepressants for 9 months or longer, and are currently taking citalopram 20 mg, sertraline 100 mg, fluoxetine 20 mg, or mirtazapine 30 mg, but are well enough to consider stopping their medication
Interventions	Intervention 1: placebo Intervention 2: long‐term maintenance Trial duration: 52 weeks
Outcomes	‐ time in weeks to the beginning of the first episode of depression ‐ depressive and anxiety symptoms ‐ adverse effects ‐ withdrawal symptoms ‐ emotional processing tasks ‐ quality of life ‐ resources and costs
Starting date	The trial began to recruit participants in March 2017; recruitment was ongoing until the end of February 2019
Contact information	larisa.duffy@ucl.ac.uk
Notes	Expected end of data collection: February 2020; paper is submitted