ISRCTN12417565.

Study name	REDUCE (Reviewing long‐term antidepressant use by careful monitoring in everyday practice) Internet and telephone support to people coming off long‐term antidepressants: protocol for a randomised controlled trial
Methods	Randomised controlled trial
Participants	Participants taking antidepressants longer than 1 year for a first episode of depression or longer than 2 years for repeated episodes of depression who are no longer depressed and want to try to taper off their antidepressant use
Interventions	Intervention 1: provision of ‘ADvisor’ Internet programmes to general practitioners or nurse practitioners and to patients designed to support antidepressant withdrawal, plus 3 patient telephone calls from a psychological well‐being practitioner Intervention 2: usual care Trial duration: 52 weeks
Outcomes	‐ depressive symptoms at 6 months ‐ depressive symptoms at other follow‐up time points ‐ anxiety ‐ discontinuation of antidepressants ‐ social functioning ‐ well‐being ‐ enablement ‐ quality of life ‐ satisfaction ‐ use of health services for costs
Starting date	Recruitment of practices began on 1 December 2019
Contact information	a.r.kendrick@southampton.ac.uk
Notes	Approximate date when recruitment of patients will be completed is 30 June 2021. End of the study is defined as the date of the last follow‐up visit of the last patient (expected to occur 12 months after the last patient is recruited)