Gibson 1998.
Study characteristics | ||
Methods | RCT (3 arms). | |
Participants | 17 women were randomised. Setting: authors from Glasgow, UK. Study dates: not reported. Inclusion criteria: women undergoing a caesarean section; either an emergency caesarean section or with other risk factors for VTE. Exclusion criteria: not reported. |
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Interventions |
Group 1 (n = 6): LMWH (enoxaparin) 20 mg once daily. Group 2 (n = 5): LMWH (enoxaparin) 40 mg once daily. Group 3 (n = 6): UFH 7500 IU every 12 hours. Intervention started after caesarean section, duration of intervention not stated. |
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Outcomes |
Review outcomes reported: symptomatic thromboembolic events; symptomatic PE; symptomatic DVT; bleeding episodes (reports "haemorrhagic event"). Other outcomes reported: anti‐Xa activity. |
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Notes | 3‐way randomisation (UFH/20 mg enoxaparin/40 mg enoxaparin). 2 enoxaparin groups combined for inclusion in the review analysis. Funding sources: not reported. Declarations of interest: not reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Described as "women were randomised". |
Allocation concealment (selection bias) | Unclear risk | Not stated. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not feasible. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No detail of blinding of outcome assessors. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No losses to follow‐up stated; no detail regarding exclusions. |
Selective reporting (reporting bias) | Unclear risk | No trial protocol to confidently assess selective reporting; furthermore data for many relevant clinical outcomes was not reported. |
Other bias | Unclear risk | Insufficient information to assess whether an important risk of bias exists. |