Comparison 2. Alpha‐blocker and usual care versus usual care: stone location subgroup (renal and proximal ureter versus distal ureter).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Stone clearance	24	2646	Risk Ratio (M‐H, Random, 95% CI)	1.21 [1.11, 1.33]
2.1.1 Renal and upper ureteral	19	1947	Risk Ratio (M‐H, Random, 95% CI)	1.15 [1.06, 1.25]
2.1.2 Lower ureteral	6	699	Risk Ratio (M‐H, Random, 95% CI)	1.40 [1.13, 1.74]
2.2 Auxiliary treatment	12	1251	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.45, 1.00]
2.2.1 Renal and upper ureteral	11	1121	Risk Ratio (M‐H, Random, 95% CI)	0.62 [0.40, 0.98]
2.2.2 Lower ureteral	1	130	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.26, 3.83]
2.3 Major adverse events	7	747	Risk Ratio (M‐H, Random, 95% CI)	0.60 [0.46, 0.80]
2.3.1 Renal and upper ureteral	6	617	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.44, 0.79]
2.3.2 Lower ureteral	1	130	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.26, 3.83]