Comparison 2. Moderate versus low protein concentration of human milk fortifier.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Weight gain (g/kg/day)	2	176	Mean Difference (IV, Random, 95% CI)	2.08 [0.38, 3.77]
2.2 Length gain (cm/week)	3	217	Mean Difference (IV, Fixed, 95% CI)	0.09 [0.05, 0.14]
2.3 Head circumference gain (cm/week)	3	217	Mean Difference (IV, Random, 95% CI)	0.13 [‐0.00, 0.26]
2.4 Mortality	1	112	Risk Ratio (M‐H, Fixed, 95% CI)	0.48 [0.05, 5.17]
2.5 Blood urea nitrogen (mmol/L)	2	165	Mean Difference (IV, Random, 95% CI)	0.44 [‐0.16, 1.03]
2.6 Incidence of necrotising enterocolitis	1	112	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 15.05]
2.7 Sepsis	1	112	Risk Ratio (M‐H, Fixed, 95% CI)	0.48 [0.05, 5.17]
2.8 Length of hospital stay (days)	1	41	Mean Difference (IV, Fixed, 95% CI)	‐3.00 [‐7.13, 1.13]