Database name	Embase Classic + Embase
Database platform	OvidSP
Dates of database coverage	1947 to 28 January 2020
Date searched	25 February 2020
Searched by	KP
Number of results	482
EndNote import order	2
Number of results once duplicates removed	378
Search strategy notes	Search lines ending in a ‘/’ are subject heading searches. Search lines beginning ‘exp’ are exploded subject heading searches. Search lines ending in .ti,ab,kw,dy. search in the title, abstract, author keywords and drug registry number fields only. Search lines ending in .ti,ab. search in the title and abstract fields only. Search lines ending in .ab. search in the abstract field only. Search lines ending in .ti. search in the title field only. Search lines ending in.pt. search in the publication type field. or/x‐y combines search sets in the range x‐y with Boolean operator OR. * is used for truncation of words. ? is used for optional wildcards. adjn searches for words within n words of each other. $n searches for words with 0‐n letters after the $.
Edits from 2017 search strategies	Edited search terms: The complete UK Cochrane Centre RCT filter for OvidSP Embase was added to the search (Lefebvre 2019). Deleted search terms: Frostnip and Chillblains were removed as these terms are outside the scope of the search.