FIG 8.

Model of HSV-1 transport into host cells. The schematic shows the molecules and intracellular signaling, which may be involved in intracellular capsid transport. Following entry into host cells, HSV-1 (McKrae) activates/phosphorylates the dynein motor and the Akt and MAPK pathways (data not shown). The major capsid protein VP5 (ICP5) and the inner tegument protein UL37 recruit the dynein motor and other accessory proteins, such as BICD2, EB1, and the dynactin complex (DCTN) to facilitate retrograde transport of virion capsids. Akt and PKC activities are required for efficient entry and transport along the microtubules toward the nucleus, where the virus replicates its DNA. (Adapted from reference 87.)