FIG 5.

miR-K12-10 may be important for KSHV-induced changes to glycolysis. Shown are the extracellular acidification rate and oxygen consumption rate of uninfected, WT-infected, or mutant-infected cell lines. Panels A and B show results for all cell lines, while panels C and D show the results only for the more divergent cell lines. The time points at which oxamate, an inhibitor of glycolysis, and rotenone, an inhibitor of oxidative phosphorylation, were added are indicated. Results are averages from 8 replicates of each cell line. Error bars show standard errors. Results from some mutants with intermediate phenotypes were omitted for clarity. (A and C) Extracellular acidification rate. (B and D) Oxygen consumption rate.