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. 2021 May 3;16(5):e0250883. doi: 10.1371/journal.pone.0250883

Table 4. Sub-group analyses of IMI techniques applying pressure to the IMI site.

Meta-analysis Number of studies Pooled SMD(95%CI) P value Heterogeneity I2 (95%CI)
All pressure based studies 10 -1.44 (-1.99,-0.89) >0.001 95% (92, 97)
Pressure techniques
    Manual pressure 4 -0.85 (-1.36,-0.33) 0.001 86% (65, 94)
    Helfer skin Tap 3 -2.95 (-5.51,-0.39) 0.024 98% (95, 99)
    ShotBlocker 2 -0.51 (-1.58,0.56) 0.347 96% (no estimate)
    Post injection massage 1 -1.86 (-2.48,-1.24) >0.001 NA
Study design
    RCTs 3 -1.67 (-3.19,-0.14) 0.032 98% (96, 99)
    Quasi experimental 7 -1.36 (-1.94,-0.78) >0.001 93% (87, 96)

NA—not assessed.