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Schematic of the general mode of action of GBM targeting NP treatments. (A) NPs in blood circulation cross the BBB via RMT. (B and C) NPs with specific-targeting ligands (e.g. transferrin or angiopep-2) conjugated to their surface reach the GBM cells where they can be taken up by receptor-mediated endocytosis which will ultimately lead to GBM cell death (not shown).
