FIG 4.

Epigenetic effects of SBHA on PEL cells. (A and B) ChIP assays for RTA (A) and vIL-6 (B) promoters. Chromatin samples were reacted with the antibody against modified histones shown at the top of each panel. The averages from three independent experiments are shown, and error bars indicate standard deviations. (C) Bisulfite sequencing of the RTA promoter. Six clones from each cell were subjected to analysis. Closed circles indicate methylated CpG sites, while open ones indicate unmethylated CpG sites. The position relative to the transcription start site of RTA is indicated above the panel.