FIG 8.

Galectin-9 (Gal-9) and TIM-3 inhibition as a joint strategy in HIV-1 latency. Bars show HIV-1 reactivation, expressed as p24 antigen production (n = 3) in a cellular model based on IL-7. Significant differences were observed after Gal-9 (2 nM) addition compared with CD4r:CD8 alone. The TIM-3 inhibition with and without Gal-9 resulted in a significant reduction in p24 antigen values. Statistical significance was calculated using the Mann-Whitney U test. P values of <0.05 were considered statistically significant. *, P < 0.05; NS, not significant. CD4r, resting CD4⁺ T cells of the cellular model.