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. 2021 Feb 10;95(5):e02214-20. doi: 10.1128/JVI.02214-20

FIG 9.

FIG 9

TIM-3 blockade improves CTL response in CD8+ T cells from PLWH. Bars show mean p24 antigen reduction (log) (n = 10). (A) Without Gal-9 addition, significant increases (*, P < 0.05) in p24 of ≥2 log with TIM-3 inhibition (α-TIM-3) (dark green bars) in the CD4:CD8 and CD4:CD8:NK cocultures were observed; no significant difference was seen in the case of CD4:NK alone. No differences were detected between results on day 7 and day 10. (B) With Gal-9 addition, significant increases in p24 of ≥2 log with TIM-3 inhibition (dark green bars) in the CD4:CD8 and CD4:CD8:NK cocultures were observed; no significant difference was seen in the case of CD4:NK alone. No differences were detected between results on day 7 and day 10. Statistical significance was calculated using the Mann-Whitney U test. P values of <0.05 were considered statistically significant. *, P < 0.05; NS, not significant.