TABLE 4.
Dissociation constants of MAbs recognizing epitopes I and III against HBV genotypes A to D
| Epitope and MAb |
KD (nM) for: |
|||
|---|---|---|---|---|
| Genotype A | Genotype B | Genotype C | Genotype D | |
| Epitope I | ||||
| BP-L34 | 3.4 | 1.4 | 0.45 | 2.7E+02 |
| BP-L41 | 2.8 | 2.4 | 2.2 | 12 |
| BP-G82 | <1.0E−03 | <1.0E−03 | <1.0E−03 | 1.5E+05 |
| BP-G88 | <1.0E−03 | <1.0E−03 | <1.0E−03 | 2.3E+03 |
| Epitope III | ||||
| BP-L03 | —a | — | <1.0E−03 | 1.6E+05 |
| BP-L07 | — | — | <1.0E−03 | — |
| BP-L13 | — | — | <1.0E−03 | — |
| BP-G87 | <1.0E−03 | — | <1.0E−03 | 1.9E+02 |
a
—, The parameter was not determined because no binding curve could be obtained.