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. 2021 Feb 10;95(5):e02190-20. doi: 10.1128/JVI.02190-20

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Copyright © 2021 Tavares et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 4 — Distribution of well-defined RNA structures across the SARS-CoV-2 genome. (A) The percentage of nucleotides in well-defined structured regions (high BPC/low Shannon) was calculated in 100-nt bins tiling the genome and is plotted as a function of the genomic coordinate (gray curve). Individual percentages of each genomic bin are also represented as a heat map in the same graph (color key on the top right-hand corner). A scheme representing the genomic divisions of SARS-CoV-2 is shown next to the plot to guide location of structured regions. (B) An expanded view of the initial two-thirds of the genome from the graph in panel A is shown along with the genomic divisions of this region (UTR plus ORF1ab and corresponding NSP divisions). (C) The downstream third of the genome is expanded from the graph in panel A to zoom in on individual structural and accessory ORFs in this region.