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. Author manuscript; available in PMC: 2021 May 3.
Published in final edited form as: Am J Obstet Gynecol MFM. 2020 Oct 27;3(1):100275. doi: 10.1016/j.ajogmf.2020.100275

FIGURE 3. AT1-AA blockade attenuates mt ROS in response to PE sera.

FIGURE 3

Preeclamptic sera increases mitochondrial ROS when incubated with HUVECs and coincubation with ‘n7AAc’ reverses the mitochondrial ROS production. HUVECs coincubated with pre-eclamptic (at <34 weeks’ gestation or >34 weeks’ gestation) serum and ‘n7AAc’ significantly reverses the mitochondrial ROS production when compared with treatment with preeclamptic (at <34 weeks’ gestaion or >34 weeks’ gestation) serum alone. Data are presented as mean±standard deviation. The asterisk indicates a significant (P<.05) difference from the control group and from the treatments with preeclamptic sera alone.

AT1-AA, angiotensin II type 1 autoantibodies; CRTL, control; mtROS, mitochondrial reactive oxygen species; PE, preeclampsia.