FIGURE 3. AT1-AA blockade attenuates mt ROS in response to PE sera.
Preeclamptic sera increases mitochondrial ROS when incubated with HUVECs and coincubation with ‘n7AAc’ reverses the mitochondrial ROS production. HUVECs coincubated with pre-eclamptic (at <34 weeks’ gestation or >34 weeks’ gestation) serum and ‘n7AAc’ significantly reverses the mitochondrial ROS production when compared with treatment with preeclamptic (at <34 weeks’ gestaion or >34 weeks’ gestation) serum alone. Data are presented as mean±standard deviation. The asterisk indicates a significant (P<.05) difference from the control group and from the treatments with preeclamptic sera alone.
AT1-AA, angiotensin II type 1 autoantibodies; CRTL, control; mtROS, mitochondrial reactive oxygen species; PE, preeclampsia.