Table 1. Overview of major protein families of Daboia russelii venoms from Sri Lanka, India and Pakistan examined under the same experimental conditions.
>Protein family/major protein subfamilies* | Relative abundance (%) | ||
---|---|---|---|
Sri Lanka (multiple locales) | India (South) | Pakistan (Sindh Delta)** | |
Phospholipase A2 (PLA2) | 63.92% | 67.50% | 63.76% |
Basic phospholipase A2 | 63.92% | 64.36% | 41.85% |
Acidic phospholipase A2 | - | 3.14% | 21.92% |
Neutral Phospholipase A2 | - | - | - |
Snake venom metalloproteinase (SVMP) | 7.34% | 0.19% | 2.52% |
Class PII | 0.19% | - | - |
P-IIa sub-subfamily | 0.05% | - | - |
P-IIb sub-subfamily | 0.14% | - | - |
Class PIII | 7.15% | 0.19% | 2.52% |
P-IIIa sub-subfamily | 3.74% | - | - |
P-IIIc sub-subfamily | 0.82% | - | - |
P-IIId sub-subfamily | 2.59% | 0.19% | 2.52% |
Snake venom serine protease (SVSP) | 5.48% | 11.86% | 5.5% |
Kunitz-type serine protease inhibitor (KSPI) | 3.03% | 5.41% | 16.0% |
Snaclec, C-type lectin & C-type lectin-like protein (CTL) | 5.23% | - | 1.3% |
Cystein-rich secretory protein (CRiSP) | 5.97% | 4.98% | 1.3% |
L-amino acid oxidase (LAAO) | 2.84% | 0.04% | 0.8% |
Snake venom metalloproteinase inhibitor (SMI) | 2.35% | - | - |
Venom endothelial growth factor (vEGF) | 2.16% | 1.55% | 4.3% |
Venom nerve growth factor (vNGF) | 0.97% | 1.68% | 1.1% |
Nucleotidase (5' NUC) | 0.45% | - | 0.1% |
Phosphodiesterase (PDE) | 0.21% | - | 2.5% |
Disintegrin (DIS) | - | 0.32% | - |
Moderate to high molecular weight proteins (MHp) | - | 6.47% | - |
Uncharacterized protein (UP) | - | - | 0.7% |
Aminopeptidase (AP) | 0.05% | - | - |
*Protein names based on sequence similarity in UniProt database through BLAST search.
**The values were according to Faisalet al. [12] reported by the same laboratory.