Table 4. Lethality of Daboia russelii venoms (Sri Lanka and Southern India) and neutralization by VPAV (Indian Polyvalent Antivenom of VINS product).

Venom	i.v. LD 50 (µg/g)	ED50 (µL of antivenom)	ER50 (mg/mL)	P (mg/mL)	n-P (mg/g)
Daboia russelii (Sri Lanka)	0.24 (0.22-0.39)	6.25 (5.04-7.75)	4.61 (3.65-11.9)	3.69	43.4
Daboia russelii (India)	0.32 (0.27-0.46)	7.83 (6.40-9.58)	4.70 (3.97-6.76)	3.76	44.3

Intravenous median lethal dose (i.v. LD₅₀): Venom dose in µg/g at which 50% of mice were dead. Median effective dose (ED₅₀): Antivenom dose in µL at which 50% of mice survived the challenge dose of 5 x LD₅₀. Median effective ratio (ER₅₀): Ratio of the amount of venom (mg) to the volume dose of antivenom (mL) at which 50% of mice survived. Potency (P): Amount of venom (mg) that is completely neutralized by a unit volume (mL) of antivenom. Normalized potency (n-P): the amount of venom (mg) that is completely neutralized per unit gram of antivenom protein.

Note: values in brackets are 95% confidence interval (CI) of LD₅₀, ED₅₀ and ER₅₀