Table 3.
Comparison of Important Genes with Somatic Alterations and Clinical Characteristics in Low-Grade (I–II) and High-Grade (III–IV) of Glioma
| Variable | I–II (N=27) | III–IV (N=56) | P |
|---|---|---|---|
| TP53 | 9 | 25 | 0.3263 |
| TERT | 4 | 24 | 0.0398 |
| IDH1/2 | 15 | 12 | 0.0019 |
| PTEN | 2 | 14 | 0.057 |
| EGFR | 0 | 13 | 0.0064 |
| ATRX | 5 | 10 | 0.9415 |
| H3F3A | 0 | 8 | 0.0388 |
| NF1 | 2 | 6 | 0.6325 |
| PDGFRA | 0 | 8 | 0.0388 |
| CIC | 6 | 1 | 0.0017 |
| PIK3CA | 0 | 7 | 0.0549 |
| SETD2 | 3 | 4 | 0.3715 |
| MET | 0 | 6 | 0.0774 |
| ATM | 1 | 4 | 0.5373 |
| BRAF | 1 | 4 | 0.5373 |
| KIT | 0 | 5 | 0.1092 |
| APC | 1 | 3 | 0.7418 |
| ARID1A | 1 | 3 | 0.7418 |
| CDK4 | 0 | 4 | 0.1546 |
| KDR | 0 | 4 | 0.1546 |
| BRCA1 | 0 | 3 | 0.2206 |
| CDKN2A | 0 | 3 | 0.2206 |
| EPCAM | 0 | 3 | 0.2206 |
| FGFR1 | 0 | 3 | 0.2206 |
| FUBP1 | 2 | 1 | 0.1986 |
| NOTCH1 | 1 | 3 | 0.7418 |
| MGMT | 18 | 25 | 0.0599 |
| 1p19q | 7 | 3 | 0.0070 |
| CNV | 0 | 26 | <0.0001 |
| Age≤40 | 14 | 15 | 0.0248 |
| Age>40 | 13 | 41 | |
| Male | 24 | 36 | 0.019 |
| Female | 3 | 20 |