TABLE 2.
CX14442 and GS-9822 retarget integration away from gene-dense regions
| Type | CX14442 (μM) | No. of unique sites | Sites in genes (%)a,c | Sites in protein coding genes (%)b,c |
|---|---|---|---|---|
| Integration site | 0 | 11,624 | 76.49 | 72.76 |
| 12.5 | 350 | 70.57 (**) | 68.86 | |
| 25 | 427 | 71.66 (*) | 68.85 | |
| MRC | 0 | 34,872 | 41.75 | 37.28 |
| 12 | 1,050 | 39.52 | 36.38 | |
| 25 | 1,281 | 40.67 | 36.85 |
a
Percentage of integration sites within genes, calculated based on the University of Califorina Santa Cruz (UCSC) genes data set, which itself is based on data from RefSeq, GenBank, the Consensus Coding Sequence (CCDS) database, and UniProt (90, 91).
b
Percentage of integration sites within protein-coding genes, calculated based on the USCS genes data set. Protein-coding genes were defined as gene entries containing a UniProt protein ID.
c
Asterisks represent a statistically significant deviation from the control data set as calculated by the Chi-square test. *, P < 0.05; **, P < 0.005; ***, P < 0.0005.
d
MRC, matched random control.