TABLE 4.

Origin, source, and antifungal susceptibility of TR-mediated azole-resistant A. fumigatus isolates in China originating from the literature, 2004 to 2020^a

Resistance mechanism	Strain ID no.	Region	Source	MIC, mg/liter
				Itra	Vori	Posa
TR34/L98H/S297T/F495I (n = 16)	247-34	Shanghai	Clinical	>16	0.5	1
51	Zhejiang	Environmental	8–16	1	0.5
C96	Shanghai	Clinical	>16	1	0.5
C485	Shenyang	Clinical	>16	2	1
E739	Beijing	Environmental	>16	2	0.5
E1001	Fuzhou	Environmental	>16	1	0.5
SHJT42b	Fuzhou	Clinical	16	2	0.5
NJ21-76	Nanjing	Clinical	16	0.25	0.5
20643.017	Hangzhou	Clinical	16	2	2
20643.023	Hangzhou	Clinical	16	2	2
20677.079	Hangzhou	Clinical	16	1	1
20677.086	Hangzhou	Clinical	16	2	2
20677.089	Hangzhou	Clinical	16	4	2
20684.002	Hangzhou	Clinical	16	2	2
20684.007	Hangzhou	Clinical	16	2	2
20684.022	Hangzhou	Clinical	16	2	1
TR34/L98H n = 11	AF.44	Nanjing	Clinical	>8	4	0.5
AF.98	Nanjing	Clinical	>8	2	0.25
STJ0048	Fuzhou	Clinical	>16	1	1
STJ0049	Fuzhou	Clinical	>16	1	1
XJ138	Urumqi	Clinical	16	2	0.5
C94	Shanghai	Clinical	≥16	2	1
C116	Fuzhou	Clinical	≥16	4	0.5
C135	Fuzhou	Clinical	≥16	2	0.5
C136	Fuzhou	Clinical	≥16	2	0.5
C821	Chengdu	Clinical	≥16	4	1
SHJT40	Shanghai	Clinical	16	1	0.5
TR34/L98H/S297T n = 2	STJ0107	Shanghai	Clinical	>16	0.5	1
STJ0140	Nanjing	Clinical	>16	0.5	1
TR46/Y121F/T289A n = 3	15	Zhejiang	Environmental	0.5	8–16	0.25
44	Zhejiang	Environmental	0.5	8–16	0.25
C195	Beijing	Clinical	1	≥16	0.5

^aThese data originated from the literature (7, 13, 15–18, 23, 24). Abbreviations: Itra, itraconazole; Vori, voriconazole; Posa, posaconazole.