FIG 6.
Probabilities of target attainment (PTAs) of achieving a fAUC24h/MIC value of 111.1 with six different dosing regimens (1,500 mg at day 1; 1,000 mg at day 1 and 500 mg at day 8; 1,500 mg at days 1 and 8; 1,500 mg at day 1, 1,500 mg at day 8, and 500 mg at day 36; 1,500 mg at day 1, 1,500 mg at day 8, and 1,000 mg at day 36; and 1,500 mg at day 1, 1,500 mg at day 8. and 1,500 mg at day 36). The histograms are the MIC distribution frequencies of 801 Staphylococcus aureus isolates yielded from bone and joint infections in 78 European and U.S. hospitals between 2011 and 2016 (14). The dotted lines identify desirable PTA (≥90%).