TABLE 1.
Characteristics of the study population (n = 15)
| Characteristica | Value |
|---|---|
| Age (median [range] [yrs]) | 60 (51–72) |
| Gender (no. male/no. female [%]) | 8/7 (53.3/46.7) |
| Body wt (median [range] [kg]) | 71 (66.5–82.5) |
| BMI (median [range] [kg/m]) | 26.7 (25.0–27.5) |
| eGFR (median [range] [ml/min/1.73 m2]) | 98.0 (91.0–105.0) |
| Albumin (median [range] [g/liter]) | 3.9 (3.6–4.3) |
| Type of infection (no. [%]) | |
| Prosthetic joint infection | 11 (73.3) |
| Implant-associated osteomyelitis | 2 (13.3) |
| Spondylodiscitis | 1 (6.7) |
| Septic arthritis | 1 (6.7) |
| Microbiological isolates (no. [%]) | |
| Methicillin-resistant Staphylococcus epidermidis | 7 (46.7) |
| Methicillin-resistant Staphylococcus aureus | 5 (33.3) |
| Staphylococcus hominis | 2 (13.3) |
| Enterococcus faecalis | 1 (6.7) |
| Dalbavancin plasma concentrations (median [range] [mg/liter]) | |
| Peak concentrations at 2 h | 84.8 (72.2–105.3) |
| Trough concentrations at 168 h | 19.5 (15.4–26.7) |
| Peak concentrations at 170 h | 106.0 (91.4–154.0) |
| Treatment outcome (end of treatment) (no. [%]) | |
| Cured | 13 (86.7) |
| Failed | 2 (13.3) |
a
BMI, body mass index; eGFR, estimated glomerular filtration rate calculated by means of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula.