TABLE 3.

Estimates of the final population pharmacokinetic model and bootstrap results based on 1,000 simulations

Parameterc	Final model		Bootstrap results
	Estimate	% RSE	Median	5th to 95th percentiles
Fixed effects
CL (liter/h)	0.106	9.33	0.104	0.1–0.110
V1 (liter)	17.40	12.0	17.16	16.52–17.96
Q (liter/h)	0.103	37.4	0.093	0.05–0.162
V2 (liter)	15.10	15.8	15.04	14.07–16.80
t1/2 (days)	11.29a	11.68a
Vss (liter)	36.40a	35.88a
Random effects (CV [%])
IIVCL	36.21	20.7	36.42	33.05–37.34
IIVV1	44.27	22.4	40.29	35.14–47.51
IIVQ	130.46	33.7	121.96	83.38–174.85
IIVV2	62.34	22.2	69.16	55.53–76.33
IIVt1/2	54.37b	53.53b
IIVVss	50.59b	48.61b
Residual variability
b (proportional)d	0.18	7.76	0.18	0.17-0.19

^aCalculated from individual parameter values with microconstants, $t_{1/2}=0.693/\left[0.5\times \left(k+k_{12}+k_{21}\right)-\sqrt{{\left(k+k_{12}+k_{21}\right)}^2-\left(4\times k\times k_{21}\right)}\right].$

^bCalculated as (standard deviation/mean) × 100.

^c% RSE, relative standard error of the estimate; CV, coefficient of variation; CL, total body clearance; V₁, central volume of distribution; Q, intercompartmental clearance; V₂, peripheral volume of distribution; V_ss, volume of distribution at steady-state; t_1/2, terminal half-life; IIV, interindividual variability (associated with CL [IIV_CL], with V₁ [IIV_V1], with Q [IIV_Q], with V₂ [IIV_V2], with t_1/2 [IIV_t1/2], and with V_ss [IIV_Vss]).

^dProportional residual error model.